INGA: protein function prediction combining interaction networks, domain assignments and sequence similarity
نویسندگان
چکیده
منابع مشابه
INGA: protein function prediction combining interaction networks, domain assignments and sequence similarity
Identifying protein functions can be useful for numerous applications in biology. The prediction of gene ontology (GO) functional terms from sequence remains however a challenging task, as shown by the recent CAFA experiments. Here we present INGA, a web server developed to predict protein function from a combination of three orthogonal approaches. Sequence similarity and domain architecture se...
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Most of a cell’s functional processes involve interactions among proteins, and a key challenge in proteomics is to better understand these complex interaction graphs at a systems level. Because of their importance in development and disease, protein-protein interactions (PPIs) have been the subject of intense research in recent years. In addition, a greater understanding of PPIs can be achieved...
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متن کاملGlobal protein function prediction in protein-protein interaction networks
A. Vazquez, A. Flammini, A. Maritan and A. Vespignani 1 Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA 2 International School for Advanced Studies (SISSA) and INFM, V. Beirut 2-4, 34014 Trieste, Italy 3 The Abdus Salam International Centre for Theoretical Physics, P.O. Box 586, 34100 Trieste, Italy and 4 Laboratoire de Physique Theorique (UMR du CNRS 8627), atiment 2...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2015
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkv523